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The Motorola F3/MOTOFONE was the first (and still is the only?) mobile phone with an e-paper display. Although this is not a pixel-based display, like found in eBook-readers (e.g. the Amazon Kindle or the B&N nook), it is still quite nice for experimenting with low power microcontroller projects.
E-paper/bistable displays have the ability to sustain the display content even without the supply of power, so initial idea I had was to build something like a clock, only powering the display when updating it every minute.
The display consists of 182 individually drivable segments, which form a row of six 14-segment characters, a row of six 8-segment characters, and many symbols used for user notification and the menu.
As you can see from this picture, the used display controller is a Solomon Systech SSD1621. Unfortunately there is no public datasheet, so I had to sniff the (32 bit) SPI communication between the TI Locosto baseband processor and the display. The protocol turned out not to be very difficult, just some initialization, some commands for actually writing the display content, and a command to refresh the display with the just transmitted content.